Gut-Microbiome-Brain Interactions and Mental Health (R21/R33)

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This Funding Opportunity Announcement (FOA) encourages research grant applications from institutions/organizations to investigate mechanisms by which the gut microbiome modulates the development and function of brain circuits that subserve behavioral functions of direct relevance to the mission of the NIMH. Because initial colonization of the gut by microbiota occurs early in life and may influence the subsequent development and modifiability of the central nervous system, developmental studies are of interest. Applicants may propose to use wild-type, gnotobiotic, and/or specific pathogen-free model organisms. With this FOA, the NIMH encourages investigator teams to initiate hypothesis-driven research in this cross-cutting research area and to identify promising mechanistic leads for future basic and translational research that will advance the mission of the NIMH.

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