Identification and Characterization of Molecular Targets Within the mTOR Pathway With Potential to Impact Healthspan and Lifespan (R21)

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Purpose. This FOA issued by the National Institute on Aging and the National Cancer Institute encourages grant applications focused on: 1) identifying novel targets within the mTOR (mammalian target of rapamycin) signaling network, the manipulation of which has the potential to promote healthy aging, i.e. extend health span in the aged (NIA interest); and 2) identifying and characterizing dietary constituents that modulate the mTOR pathway and promote cancer prevention (NCI interest). Identification and characterization of targets can utilize a wide range of approaches, including medicinal chemistry, in vitro assays, and studies in lower organisms or mammalian models. Mechanism of Support. This FOA will use the NIH Exploratory/Developmental (R21) award mechanism. Funds Available and Anticipated Number of Awards. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received.

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