Identification of Novel Targets and Pathways Mediating Weight Loss, Diabetes Resolution and Related Metabolic Disease after Bariatric Surgery in Humans (R01)

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This Funding Opportunity Announcement (FOA) will support applications that address the mechanisms by which novel, unexplored targets and pathways, or known targets, mediate the sustained weight loss, diabetes resolution and improvements in other obesity-related metabolic diseases reported following bariatric surgery in humans. Studies directly addressing novel mechanisms using targeted approaches are of interest and responsive to this FOA particularly those which utilize up-to-date sophisticated methodologies. Studies simply identifying differences in responses before and after surgery that do not address mechanism will not be considered responsive. Only studies involving human subjects will be considered.

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