Immunity in Neonates and Infants (U01)

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This Funding Opportunity Announcement (FOA) invites applications from institutions and organizations to participate in a cooperative research group, focusing on elucidating mechanisms regulating the development and function of the immune system in neonates (0-28 days) and infants (29 days 12 months), including immune mechanisms triggered by non-pathogenic or pathogenic microbes (including HIV), vaccines, exposure to allergens, or alterations in immune function due to environmental exposures to pollutants. The purpose of this FOA is to advance current knowledge of the developing immune system during the first year of life and to encourage innovative approaches to more fully understand the distinct characteristics of neonatal/infant immune responses. Better understanding of infant and neonatal immune development has the potential to improve public health by providing a foundation for guiding the maturation of a healthy (protective) immune system and reducing the development of immune-mediated disorders, reducing susceptibility to infections and allergens, and improving immune responses to vaccines in these vulnerable populations.

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