Immunity in the Elderly (R01)

archived

The National Institute of Allergy and Infectious Diseases (NIAID) and the National Institute of Aging (NIA) invite applications to define the mechanisms for induction, development, and maintenance of protective immunity in the elderly in response to infections with or vaccinations against NIAID Emerging and Re-emerging Infectious Diseases (http://www.niaid.nih.gov/topics/emerging/Pages/list.aspx). The goal of this FOA is to develop a better understanding of the immune mechanisms involved during the aging process that contribute to impaired immune responses resulting in severe infections and dampened responses to vaccines in this population. This FOA requires human studies, to gain insights into immune changes in elderly individuals. Thus, at least one aim of the project must focus fully on human studies; appropriately justified animal work may be included in additional aims to conduct mechanistic studies that are not possible in humans.

High