Immunobiology of Xenotransplantation (U01, U19)

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Purpose. The National Institute of Allergy and Infectious Diseases (NIAID) invites new or renewal applications to participate in the Immunobiology of Xenotransplantation Cooperative Research Program (IXCRP) for the development of pre-clinical porcine to non-human primate (NHP) models of islet, kidney, heart, lung, or liver xenotransplantation. The goals of this program are to: (1) delineate the cellular and molecular mechanisms of xenograft rejection and the induction of tolerance; (2) develop effective strategies to improve xenograft survival; and (3) characterize the physiological compatibility/limitations of xenografts. The long-term goal of this program is to develop novel and effective strategies for application of xenotransplantation in the clinic. Mechanism of Support. This FOA will use the single project (U01) and multi-project (U19) Cooperative Agreement grant mechanisms. Funds Available and Anticipated Number of Awards. The NIAID intends to commit $2.5 million total costs in FY 2010 to fund two to four new or renewal U01 and/or U19 awards in response to this FOA. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications.

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