Increasing the Service Life of Dental Resin Composites (R21)

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Purpose. The long term goal of this initiative is to increase the service life of dental resin composite restorations.The objective of this initiative is to better understand how degradation due to either physical and environmental factors and/or the composition of dental resin composites interacting with the biofilm in the oral cavity facilitates the development of secondary decay. This initiative will stimulate multidisciplinary research to develop methods to assess the clinical success of dental resin composite materials as a restorative material, and encourage research for improving this material and/or for the development of new restorative materials.Mechanism of Support. This FOA will utilize the R21 high impact exploratory grant mechanism and runs in parallel with an FOA of identical scientific scope, RFA-DE-10-004, utilizing the R01 research project grant mechanism.Funds Available and Anticipated Number of Awards. NIDCR intends to commit $3 million total costs in FY2010 to support meritorious projects solicited through this FOA and RFA-DE-10-004. We anticipate that 3-4 R21 awards will be made, pending the number and quality of applications and availability of funds.Budget and Project Period. Direct costs are limited to $275,000 over an R21 two-year period, with no more than $200,000 in direct costs allowed in any single year. The total project period for an application submitted in response to this funding opportunity may not exceed two years.Application Research Plan Component Length: The R21 application Research Plan component of the PHS398 (Items 3-5) may not exceed 6 pages, including tables, graphs, figures, diagrams, and charts.Eligible Institutions/Organizations. Institutions/organizations listed in Section III, 1.A. are eligible to apply. Eligible Project Directors/Principal Investigators (PDs/PIs). Individuals with the skills, knowledge, and resources necessary to carry out the proposed research are invited to work with their institution/ organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.

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