Interactions between Physical Activity and Drug Abuse (R01)

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-Purpose. The goal of this Funding Opportunity Announcement (FOA) is to stimulate investigations, using animal models or human subjects, of neurobiological and behavioral mechanisms that underlie the effects of physical activity on brain function across the lifespan as well as research designed to improve the translation of existing knowledge of the effects of exercise and physical activity into strategies for the prevention and treatment of drug abuse. The proposed line of investigation may focus on any neurobiological, behavioral or cognitive process that has been demonstrated to be affected by drugs of abuse or behaviors related to drug abuse. The research may be conducted in healthy individuals or, if scientifically appropriate, may include substance-abusing populations. All applications, however, must address how the proposed investigations are relevant to the understanding and/or treatment of substance abuse or how they may be implemented in substance abusing populations.  -Mechanism of Support. This FOA will utilize the R01 award mechanism and also allow for revision (formerly ¿competing supplemental¿ or ¿Type 3¿) applications to existing R01 human subject grants. The FOA runs in parallel with one other FOA of identical scientific scope that solicits applications under the Small Research Grant (R03) award mechanism. Applicants under the R03 mechanism should refer to RFA-DA-09-014. -Funds Available and Anticipated Number of Awards. NIDA intends to commit $4 million dollars in FY2009 to fund 8 to 12 applications in response to this FOA and its companion RFA (DA-09-014).

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