International Epidemiologic Databases to Evaluate AIDS (IeDEA) (U01)

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Purpose. This Funding Opportunity Announcement (FOA), issued by the National Institute of Allergy and Infectious Diseases (NIAID), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and the National Cancer Institute (NCI), National Institutes of Health (NIH) solicits single project Cooperative Agreement (U01) applications from institutions/organizations to continue and expand the International Epidemiologic Databases to Evaluate AIDS (IeDEA) Program. The IeDEA Program is comprised of 7 regional data center awards each of which brings together clinical and research data resources to answer questions concerning HIV/AIDS. NIAID recognizes that HIV/AIDS does not occur in isolation and is also interested in the epidemiology of tuberculosis (TB), malaria, the impact of HIV on the incidence, prevalence and spectrum of cancer, and other infectious diseases among adults and children in communities affected by HIV/AIDS. Through regional data centers in specific geographic areas, IeDEA is intended to promote the performance of regional and global research in the fields of HIV/AIDS clinical epidemiology, comparative effectiveness, implementation science, and cost-effectiveness through the use of data from different settings and populations to more accurately define and monitor HIV/AIDS and TB, malaria, cancer and other infectious disease (HTMC&O) epidemics in the context of HIV/AIDS. IeDEA is also intended to facilitate the development of methods and standards of data collection and harmonization to enhance the quality of observational databases at the local level. These efforts should improve scientific capacity locally and increase opportunities for future collaborative efforts. Through the expansion and support of complex statistical methods for the analysis of large observational databases, this research program also intends to further the field in novel and innovative ways. While the primary focus of this initiative is HIV/AIDS, the methods and harmonization activities are expected to have utility in other infectious disease areas. Mechanism of Support. This FOA will utilize the U01 award mechanism. Funds Available and Anticipated Number of Awards. NIAID, NCI and NICHD intend to commit approximately $10.5 million (U.S.) dollars in FY2011 to fund up to 7 IeDEA regional data centers and 1 IeDEA Coordinating Award in response to this FOA. All applicants may request a project period of up to five years.

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