Interpreting Variation in Human Non-Coding Genomic Regions Using Computational Approaches and Experimental Assessment (R01)

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This Funding Opportunity Announcement (FOA) solicits applications to develop highly innovative computational approaches for interpreting sequence variants in the non-protein-coding regions of the human genome. The goal is to develop methods that analyze whole-genome sequence data by integrating data sets, such as ones on genome function, phenotypes, patterns of variation, and other features, to identify or substantially narrow the set of variants that are candidates for affecting organismal function leading to disease risk or other traits. The accuracy of the computational approaches developed should be assessed using experimental data.

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