Letting up senescence and inflammaging through T cells

ongoing

With the increase in human life expectancy, there is an urgent need to understand the common molecular pathways by which aging results in a progressively higher susceptibility to chronic morbidity, disability, and frailty. In the last years, immunometabolism has emerged as a new field to boost immune responses for cancer immunotherapies as well as to dampen autoimmune diseases. A recent discovery from my lab has revealed the critical role of T cell metabolism in accelerating the onset of age-associated diseases and multimorbidity. This finding has opened a new path to investigate the diverse T cell intrinsic and external stimuli that instruct T cell differentiation towards a dysfunctional state during aging, with the final goal of designing effective strategies to promote healthy aging. LetTBe will address the hypothesis that the time-dependent deterioration of T lymphocytes contributes not only to immunosenescence but also to the general aging process. The LetTBe project proposes to use multidisciplinary approaches to target age-associated T cells for preventing inflammaging, senescence and age-associated multimorbidity. Our central goals are: 1) To define age-associated T cells heterogeneity with special focus in their cellular origin, clonality, metabolic vulnerabilities and transcriptomic signatures; 2) To decode the environmental signals that are imprinted on age-associated T cells and contribute to their development; 3) To identify new strategies to targeting age-associated T cells for slowing down immunosenescence, and for boosting resilience to inflammaging, systemic senescence and age-related multimorbidity. In sum, LetTBe puts forward an ambitious but feasible program with the wide purpose of understanding the specific molecular mechanisms and metabolic requirements of age-associated T cells, with the final goal to guide new strategies to improve healthy aging.