Life After Linkage: The Future of Family Studies (R01)

archived

This FOA issued by NHLBI and NHGRI solicits applications which integrate novel molecular data with existing genotype and phenotype data in families to identify and characterize genes influencing complex disorders. Applications for this program should have previously examined families with some genotyping and phenotypes available. Proposals may utilize focused ascertainment from families, for example, using risk profile, extreme phenotypes or families contributing heavily to genomic signals. The program may support the addition of targeted or whole genome sequencing, exon sequencing, copy number variants (CNVs), expression profiling, metabolomics, epigenomics, and/or novel biomarkers. This may require additional sample collection and/or reconsent. Applications should include a strong analytic component focused on bioinformatics and integration of multiple data types.

High