Limited Competition: Continued Development of the Gabriella Miller Kids First Pediatric Data Resource Center (U2C Clinical Trial Not Allowed)

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This limited competition Funding Opportunity Announcement (FOA) solicits applications for the continued development of the Gabriella Miller Kids First Pediatric Data Resource Center (DRC), which consists of the following components: a Data Resource Core, a Data Coordination Core, and an Administrative and Outreach Core. The goal of the cloud-based Data Resource is to accelerate discovery of genetic etiology and shared biologic pathways within and across childhood cancers and structural birth defects by facilitating access to and querying of annotated genomic sequence and phenotypic data from cohorts of patients with these conditions. The Data Resource Core will continue to develop the Data Resource, which serves as an indispensable research resource where genomic and phenotypic data can be aggregated, accessed, analyzed, and shared within and across the childhood cancer and structural birth defects research communities as well as the broader scientific community. The Data Coordination Core will work with Kids First investigators and sequencing centers to facilitate data collection, harmonization, and sharing. The Administrative and Outreach Core will oversee administrative activities, work closely with the NIH Kids First Working Group, and provide outreach and education to the research community on using the Data Resource.

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