Limited Competition: Genome Sequencing Center for the Gabriella Miller Kids First Pediatric Research Program (U24 Clinical Trial Not Allowed)

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The purpose of this Funding Opportunity Announcement (FOA) is to renew the Genome Sequencing Center(s) for the Gabriella Miller Kids First Pediatric Research Program to support rapid generation of high quality sequence and variant data (whole genome, RNA, and long-read), genome-wide methylation profiling, and chromatin accessibility data from a large number of human specimens representing two types of pediatric conditions - childhood cancers and structural birth defects. All data generated under this FOA will be re-processed and harmonized by the Gabriella Miller Kids First Pediatric Data Resource Center (Kids First DRC), which is also charged with maintaining a public-facing, cloud-based resource that enables researchers to search, access, aggregate, analyze, and share annotated genomic sequences, genomic variants, epigenomic, transcriptomic, and phenotypic datasets. Together these resources promote comprehensive and cross-cutting research and collaboration within the pediatric research community.

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