Limited Competition: Large-Scale Collaborative Project Award Renewals (U54)

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The purpose of this funding opportunity announcement (FOA) is to invite the submission of renewal applications and to describe application, review, and award procedures for the renewal of large-scale collaborative project awards that were awarded under PAR-07-412, "Large-Scale Collaborative Project Awards (R24/U54)."This announcement applies to awards whose support from the National Institute of General Medical Sciences (NIGMS) for the Phase II application began in FY 2010.New applications for large-scale collaborative project awards are not being accepted by NIGMS and are not part of this FOA.Currently active large-scale collaborative project awards in their first period of support are eligible to compete for one renewal period of up to five additional years of support.These awards are intended to solve critical, complex biological problems within the mission of NIGMS by supporting a team of independently-funded investigators to synergize and integrate their research efforts.Critical elements of these multi-component renewal applications will include evidence that a highly integrated and functioning team has been established; that excellent progress is being made; that the progress makes accomplishment of the final goals in the next time period feasible; that results have been achieved that could not have been accomplished by individual efforts alone; that plans for the next project period are compelling; and that plans have been made to accommodate the termination of NIGMS support at the end of that period.Overall, the applications should describe the proposed and unanticipated challenges that were met, how the project has evolved, where it stands currently, and how the final phase will be achieved.

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