Limited Competition Multicenter AIDS Cohort Study (MACS) Clinical Research Sites (U01)

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The purpose of this FOA is to renew the clinical research sites (CRSs) of the Multicenter AIDS Cohort Study (MACS) and continue support for clinical, epidemiologic and basic research on a cohort of men who report sex with men (MSM). The MACS will continue to characterize the long-term, natural and treated history of HIV infection in MSM, provide insight into the clinical epidemiology of HIV, and further our understanding of predictors of disease among HIV positive MSM. The MACS CRSs will also transition to a rolling cohort design to replace existing cohort members who die or otherwise are permanently lost to follow-up. Due to the demonstrated capacity to recruit and retain this unique population, the depth of data and specimens collected over decades, and the need for continued follow-up, this competition will be limited to the current four clinical awardee institutions for the MACS CRSs.

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