Limited Competition: NIDCD National Temporal Bone, Hearing and Balance Pathology Resource Registry (U24 Clinical Trial Not Allowed)

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The NIDCD Temporal Bone Registry is a national research resource for human auditory and vestibular research. Its fundamental purpose is to coordinate information about specimens of the human ear and to recruit potential temporal bone donors. The Registry coordinates specimen collection, information recording and data management of specimens, and provides public information, including an up-to-date website about human ear specimens for research. It is not a simple database or tissue bank for human ear specimens. Applications are encouraged that will enhance, promote, and support critical research on the human middle and inner ear that cannot be done in living humans. Use of temporal bone specimens also provides an opportunity for translation from critical animal models to human models for auditory and vestibular research. This initiative will support the Registry by cooperative agreement, to: continue to develop and maintain a growing database for access to detailed information about the location, condition, and other bioinformatics data about new and archival human temporal bone tissues around the country that are available as resources for auditory and vestibular research; communicate with scientific and clinical researchers to disseminate information about the resources available; maintain a well-organized nationwide network of on-call experts for timely post-mortem harvesting of temporal bone tissues; develop and implement a strategy for receipt of harvested tissue by nearby temporal bone laboratories; develop new methods or techniques for donor recruitment and post-mortem tissue procurement; communicate with pledges for tissue donation combined with relevant medical histories that will allow linking functional disorders to morphological, biochemical and genetic pathologies; provide education/outreach to the scientific community and to the public about temporal bone donations.

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