Limited Competition: The Health and Retirement Study and Harmonized Cognitive Assessment Protocol (U01 Clinical Trial Not Allowed)

closed

The purpose of this limited competition FOA is to solicit an application to continue data collection, development, and dissemination of the Health and Retirement Study (HRS). The HRS is a longitudinal panel study that surveys a nationally representative sample of approximately 20,000 people aged 50 and older in the United States via mixed-mode data collection to support multidisciplinary research on life course health and aging. This renewal provides additional research opportunities to use HRS to study Alzheimers Disease and Related Dementias (AD/ADRD) formally including a companion project, the Harmonized Cognitive Assessment Protocol (HCAP), that included a neuropsychological assessment battery as well as informant reports to better characterize cognitive function. This single integrated award combining HRS and HCAP will also add important additions recommended by subject matter experts to enhance HRS/HCAP to facilitate research on AD/ADRD: additions of larger samples of Black and Hispanic populations in HCAP; contextual data to capture new elements of the exposome ranging from microscopic to macro level exposures; improving overall response/retention rates to maintain representativeness; enhanced data on occupational exposures/characteristics; expanded aging and AD/ADRD-relevant blood-based biomarkers; additional content on social factors to study racial disparities and minority health via life histories as well as the medium and long-term social impacts of the COVID-19 pandemic.

High