Maternal and Pediatrics Precision in Therapeutics Hub (MPRINT) (P30 Clinical Trial Not Allowed)

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This Funding Opportunity Announcement (FOA) invites applications to form the Knowledge and Research Coordination Center (KRCC) of the NICHDs Maternal and Pediatric Precision in Therapeutics (MPRINT) Hub. The MPRINT Hub will serve as a national resource for expertise in maternal and pediatric therapeutics to conduct and foster therapeutics-focused research in obstetrics, lactation, and pediatrics while enhancing inclusion of people with disabilities. By serving as a national resource, it will aggregate, present, and expand the available knowledge, tools, and expertise in maternal and pediatric therapeutics to the broader research, regulatory science, and drug development communities. The MPRINT KRCC will coordinate and support the operations of the entire MPRINT Hub, interface with Centers of Excellence in Therapeutics (CETs; RFA-HD-21-026), and develop a web portal to access an underlying curated knowledge base of maternal and pediatric pharmacology and therapeutics. This knowledge base will aggregate and identify knowledge deficits in the principles of maternal and pediatric therapeutics including pharmacokinetics, pharmacodynamics, genetics, proteomics, and metabolomics that inform drug development and regulatory science. The MPRINT KRCC will serve as the primary administrative component and public-facing component of the MPRINT Hub as well as a conduit to the resources in its other components such as the MPRINT CETs. Additionally, the MPRINT KRCC will oversee an Opportunity Pool of funds to address emergent needs in support of national research in maternal and pediatric therapeutics.

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