Mechanism-Focused Research to Promote Adherence to Healthful Behaviors to Prevent Mild Cognitive Impairment (MCI) and Alzheimers Disease and Related Dementias (AD/ADRD) (R61/R33 Clinical Trial Required)

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The ultimate goal of this R61/R33 Funding Opportunity Announcement (FOA) is to identify meaningful (e.g., causal), modifiable factors that promote adherence to lifestyle changes or to other (e.g., cognitive training) behaviors that hold potential for prevention of cognitive decline, MCI, and AD/ADRD. Specifically, this will be done by conducting research to understand how, why, and for whom particular features of behavior change interventions engage specific psychological or interpersonal processes that promote maintenance of (adherence to) health behaviors. Applications in response to this FOA (and to the companion R01 FOA) should be framed within the NIH Stage Model. Additionally, this FOA supports new early- to late- stage (including Stages I-IV) research projects. Projects should create, refine, and test interventions that target individual- and interpersonal-level mechanisms of adherence to healthful behavioral patterns and to other prevention approaches for cognitive decline, MCI, and AD/ADRD (e.g., cognitive training). Additionally, this FOA supports studies that integrate basic science questions of how psychological and interpersonal targets (i.e., processes we can manipulate) and mechanisms may inform the design and development of effective, efficient, and personalized approaches to promote adherence to behavior change for the prevention of AD/ADRD and to help optimize healthy aging over the life course.

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