Mechanism of Alcohol-Induced Organ Damage (R01)

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Purpose. This Funding Opportunity Announcement (FOA) issued by the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, solicits Research Project Grant (R01) applications to study molecular and cellular mechanisms of alcohol-induced organ damage. Excessive alcohol consumption can damage all organ systems including the liver, heart, pancreas, lung, endocrine and immune systems, as well as bone and skeletal muscles. The mechanisms for these alcohol-induced tissue injuries are currently not fully understood. NIAAA is especially interested in integrative research that elucidates complex mechanisms of injury either common or unique to each organ system. This FOA also encourages the study of alcohols effect on stem cell, embryonic development, and regeneration. A better understanding of these underlying mechanisms may provide new avenues for developing more effective and novel interventions for prognosis, diagnosis, and treatment of alcohol-induced organ damage. This FOA also aims to foster the utilization of innovative experimental design and emerging technologies, such as functional genomics, systems biology, as well as novel microscopic imaging techniques, to generate new mechanistic and clinical insights into alcohol-induced tissue injuries. Use and development of animal and culture cell models are integral to this effort and encouraged along with studies involving human subjects.

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