Metals in Medicine (R01)

archived

Purpose. The objective of this Funding Opportunity Announcement (FOA), issued by the National Institute of General Medical Sciences (NIGMS), National Cancer Institute (NCI), National Institute of Environmental Health Sciences (NIEHS), and the Office of Dietary Supplements (ODS), National Institutes of Health is to encourage research that bridges the areas of inorganic chemistry and medicine. The mechanisms by which organisms control transition metal ions and the roles of these metals in cellular regulation and signaling in health and disease are of principal interest. The interactions of synthetic inorganic complexes with living systems and their components are an additional area of interest. These areas are linked by the need to involve researchers having a deep understanding of inorganic chemistry in medically relevant research. Much of the work is expected to involve collaborations including chemists, biologists, and medical researchers. The results will be relevant to understanding the mechanisms of metal handling by biological systems and the basic cellular roles underlying the nutritional requirement for essential metals. It is expected that this research will also contribute to the identification of new targets for drug discovery, diagnostics, and future therapeutic approaches involving metal complexes, although drug development, per se, is not a focus of the program.

High