Modeling Immunity for Biodefense (U19)

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This Funding Opportunity Announcement (FOA) solicits applications from single institutions, or consortia of institutions, to participate in a network of research groups developing computational models of immunity to infectious diseases other than HIV/AIDS. Applications are sought to develop, refine and validate computational models of immune responses (1) during or following infection, and/or (2) before and after vaccination against an infectious disease, through an iterative approach involving computational studies and immunological experimentation. The main goal of this FOA is to advance our understanding of the complex immune mechanisms triggered by infection and/or vaccination through the development and application of computational models of immunity, coupled with immunological experimentation to validate and improve the utility and robustness of the computational models.Another goal of this FOA is to make the computational models and data developed under this initiative readily available to the broader research community for further refinement or direct use in biological experimentation. This program will also support pilot projects, workshops, and symposia to foster the use of computational models of immunity by the broader research community.

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