Molecular Approaches to Diet and Pancreatic Cancer Prevention (R01)

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Purpose. This Funding Opportunity Announcement (FOA) issued by the National Cancer Institute (NCI) and the National Institute on Alcohol Abuse and Alcoholism (NIAAA) encourages grant applications that propose innovative preclinical and clinical studies to determine how dietary energy intake and bioactive food components, including alcohol, influence pancreatic cancer development and prevention. This FOA seeks to encourage collaboration between nutritional scientists, cancer biologists, oncologists and gastroenterologists to jointly examine key mechanisms in the pancreatic cancer process (e.g., carcinogen metabolism, cell division, differentiation, apoptosis) in order to explore mechanistic links between quantity and form of energy consumed, and/or bioactive food component intakes with pancreatic tumor incidence and behavior. The linkage between diet and pancreatic cancer comes from its long-recognized interrelationships with diabetes and obesity, and thus with caloric intake and expenditure. This FOA seeks to expand research that will clarify the importance of diet-related energetics and bioactive food components in pancreatic cancer prevention. Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism. Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism, numbers, quality, duration, and cost of the applications received.

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