Molecular Mechanisms of Combination Adjuvants (MMCA)(U01)

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This Funding Opportunity Announcement (FOA) solicits applications that propose studies of the mechanism of action of a combination of two or more vaccine adjuvants (combination adjuvant). Adjuvants that are used in these studies must already have shown immune boosting activity when used individually in licensed or unlicensed vaccines (e.g. experimental or candidate vaccines). The purpose of this FOA is to build upon the investment the NIAID has already made into adjuvant research, by combining previously identified and characterized adjuvants and characterizing their immune stimulating activity. The Cooperative Agreement grant mechanism allows for coordination of these research efforts with NIAIDs overall adjuvant research objectives. The long-term goal is to promote the development of novel adjuvant combinations which will improve the immunogenicity of vaccines while addressing concerns related to reactogenicity.

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