Mutant Mouse Regional Resource Centers (Limited Competition U42)

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Purpose. The National Center for Research Resources (NCRR) invites applications for a limited competition Funding Opportunity Announcement (FOA) for the continued support and advancement of the Mutant Mouse Regional Resource Centers (MMRRC). The MMRRC project is expected to facilitate research by identifying, acquiring, evaluating, characterizing, cryopreserving, and distributing mutant mouse strains to qualified biomedical investigators. A regional network of three repositories collectively operates, using a mutually agreed upon, defined set of standard operating procedures to serve the needs of the biomedical research community for transgenic, knockout and other genetically-induced mutant mice. Each center is responsible for importing mice from assigned donating investigators, and establishing banks of cryopreserved sperm, embryos, and related materials for distribution to research investigators. The PI of each MMRRC Center is required to develop a high risk, high return, research pilot that complements the goals and needs of the MMRRC Research Consortium. Examples of projects include, but are not limited to mouse cloning, novel methods of germplasm preservation, health monitoring using biosensors, and assisted reproductive technologies. The overall objective of this limited competition FOA is to support the continued availability of mutant mice to biomedical researchers in the United States (US). This limited competition FOA will use the U42 cooperative agreement mechanism to continue support for the resource.

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