Mutant Mouse Regional Resource Centers (U42)

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Purpose. The goal of this Funding Opportunity Announcement (FOA) issued by the National Center of Research Resources, National Institutes of Health, is to solicit new applications from institutions/organizations to further advance the Mutant Mouse Regional Resource Center (MMRRC) program. The goal of the MMRRC project is to identify, acquire, evaluate, characterize, cryopreserve, and distribute mutant mouse strains to qualified biomedical investigators. A regional network of three repositories operate cooperatively, using a mutually agreed upon, defined set of standard operating procedures to serve the needs of the biomedical research community for transgenic, knockout and other genetically-induced mutant mice. Each center is responsible for importing mice from assigned donating investigators, and establishing banks of cryopreserved sperm, embryos, and related materials for distribution to research investigators. Each center also provides services on a fee-for-service basis which include: cryopreservation of mouse embryos and gametes, rederivation of living mice from cryopreserved embryos and sperm, quality control testing for mouse pathogens, and genotyping services. Mechanism of Support. This FOA will utilize the multi-project U42 Cooperative Agreement (Animal Models, and Animal and Biological Material Resource Cooperative Agreement) grant mechanism. Funds Available and Anticipated Number of Awards. A total of up to $750K in Direct Cost is available, contingent on the availability of funds. It is anticipated that one (1) new application will be made contingent on the availability of funds and the submission of meritorious applications.

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