Network of Genomics-Enabled Learning Health Systems (gLHS) Clinical Sites (U01 Clinical Trial Required)

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This Notice of Funding Opportunity (NOFO), RFA HG-23-041, invites applications for Clinical Sites (CS) to participate in a Genomic-Enabled learning health system (gLHS) Network. The Network will consist of a Coordinating Center (CC, RFA HG-23-042) and 4-6 CS working collaboratively with NHGRI to identify and improve approaches for clinical integration of genomic information in a virtuous learning health system cycle of implementation, evaluation, refinement, and re-implementation. The Network will share genomic medicine implementation practices and identify those most suitable for cross-network implementation; use these practices to conduct 2-4 implementation projects network-wide and evaluate their impact; and develop and refine successful gLHS implementation strategies as resources that can be broadly shared and adopted, including in resource-limited settings.

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