Neuroimmune Mechanisms Of Alcohol Related Disorders (R01)

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This FOA issued by National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health (NIH), encourages Research Project Grant (R01) applications from institutions/organizations that propose study the neuroimmune mechanisms of alcohol related disorders. Studies using animal models and post-mortem human alcoholic brains suggest that alcohol exposure has a significant impact on the neuroimmune system in the brain. However, it remains unclear how the altered neuroimmune factors contribute to brain and behavioral changes associated with alcohol exposure. Emerging data indicate that neuroimmune molecules are expressed in neurons and glia, and play an important role in modulating synaptic function, neurodevelopment, and neuroendocrine function. These neuromodulatory properties, together with their essential roles in neuroinflammation, provide a new frame work to understand the role of neuroimmune factors in mediating neuroadaptation, neurodegeneration, and behavioral disorders due to alcohol exposure. Studies supported by this FOA will provide fundamental insights of neuroimmune mechanisms underlying brain functional and behavioral changes induced by alcohol.

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