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Next Generation PrEP II (R01)

Sector: Hospital • Location: United States of America

Source: Grants.gov

Project
Archived

Develop the basic and preclinical framework needed for development of second and subsequent generations of PrEP agents Create a rational pipeline for the discovery of New Molecular Entities (NMEs) and the identification of existing antiretrovirals (including those that are approved for HIV treatment, and those that are not approved but may have clinical data) that can be used for the next generat

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The project “Next Generation PrEP II (R01)” is an infrastructure initiative in the Hospital sector, located in United States of America. Taiyo aggregates data on it from Grants.gov.

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Participants

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Status

Original status

archived

Taiyo status

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Contact

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Email

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Address

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Description

Description

Develop the basic and preclinical framework needed for development of second and subsequent generations of PrEP agents Create a rational pipeline for the discovery of New Molecular Entities (NMEs) and the identification of existing antiretrovirals (including those that are approved for HIV treatment, and those that are not approved but may have clinical data) that can be used for the next generation of PrEP agents Develop preclinical algorithms with clear go/no go criteria for identifying and prioritizing PrEP candidates for advancement to clinical evaluation Generate PK/PD models to assess protective effects at mucosal sites of HIV transmission Conduct proof-of-concept safety and efficacy studies in animal models

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Original Currency

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Original budget

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Source

Source reliability

High

Data quality score

100%

Source

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URL

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