Next Generation PrEP (R01)

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Purpose. The National Institute of Allergy and Infectious Diseases (NIAID) encourages applications from institutions/organizations to participate in this Funding Opportunity Announcement (FOA), Next Generation PrEP. The purpose of this FOA is to: Develop the basic and preclinical framework needed for development of second and subsequent generations of PrEP agents; Create a rational pipeline for the discovery of New Molecular Entities (NMEs) and the identification of existing antiretrovirals (approved for HIV treatment, and those that are not approved but may have extensive clinical data) that can be used for the next generation of PrEP agents; Develop preclinical algorithms with clear go/no go criteria for identifying and prioritizing PrEP candidates for advancement to clinical evaluation; Generate PK/PD models to assess protective effects at mucosal sites of HIV transmission; and Conduct proof-of-concept safety and efficacy studies in animal models. Mechanism of Support. This FOA will utilize the NIH Research project (R01) grant mechanism. Funds Available and Anticipated Number of Awards. NIAID intends to commit approximately $1.8M in FY 2011 to fund 3-5 applications submitted in response to this FOA. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications

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