NHLBI Centers for Cardiovascular Outcomes Research (U01)

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Purpose. The National Heart, Lung and Blood Institute (NHLBI) of the National Institutes of Health (NIH) solicits four-year cooperative agreement (U01) grant applications from institutions/organizations to establish three Centers for Cardiovascular Outcomes Research (CCOR) to complement and collaborate with other existing centers in cardiovascular outcomes research. This Funding Opportunity Announcement (FOA) runs parallel with a separate FOA that solicits the applications for a Research Coordinating Unit (See RFA-HL-10-018). This FOA will fund centers to conduct cardiovascular outcomes and comparative effectiveness research - natural experiments, quasi-experimental research, and practice-based trials - that focuses on patient and clinician-relevant outcomes of healthcare and the determinants of these outcomes. The goal is to directly inform public policy and/or clinical practice. Each CCOR will conduct 1-2 research projects in which multidisciplinary teams such as clinician researchers, health services researchers, biostatisticians, and/or health economists undertake novel research focusing on measuring, evaluating, and improving outcomes of cardiovascular care delivery across the care continuum. Outcomes relevant for this FOA include cardiovascular mortality, clinical events, cost-effectiveness, or quality of life. This FOA supports both methodological and applied research focused on patient outcomes. Aims could include assessing, monitoring, and enhancing the quality of cardiovascular care at patient, clinician, and system levels; translating research findings into practical care delivery strategies for clinicians and decision-makers; improving the effectiveness and efficiency of delivering evidence-based cardiovascular care; enhancing the state of the science of outcomes measurement; and developing innovative study designs and statistical methods for quasi-experimental cardiovascular research on cardiovascular care.

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