Non-Human Primate Heart/Lung Transplantation Tolerance (U01, U19)

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Purpose. The National Institute of Allergy and Infectious Diseases (NIAID) invites new or competing renewal applications from institutions to participate in the heart and lung models portion of the Non-Human Primate Transplantation Tolerance Cooperative Study Group (NHPCSG) program. The NHPCSG is a multi-center, cooperative program for research on non-human primate (NHP) models of kidney, islet, heart, and lung transplantation. The NHPCSG was established in 1999 to evaluate preclinical safety and efficacy of existing and newly developed immune tolerance induction regimens and to elucidate the underlying mechanisms of the induction, maintenance, and/or loss of tolerance in these models. The long-range goal of this program is to develop and evaluate tolerance-induction regimens that will result in enhanced long-term graft survival in clinical transplantation. The purpose of this FOA is to renew the NHP heart and lung transplantation models portion of the NHPCSG program. Mechanism of Support. This FOA will use the single project (U01) and multi-project (U19) Cooperative Agreement grant mechanisms. Funds Available and Anticipated Number of Awards. NIAID anticipates that approximately $2 million total costs will be available in FY 2010 to fund two to three new or renewal awards in response to this FOA. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications.

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