Novel Lentiviral Models of HIV Neuropathogenesis (R21)

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-Purpose. The National Institute of Neurological Disorders and Stroke (NINDS), the National Institute on Drug Abuse (NIDA), the National Institute of Mental Health (NIMH), and the National Institute on Alcohol Abuse and Alcoholism (NIAAA) invite research grant applications aimed at developing and or refinement of animal or ex vivo cell culture model systems for study of the neurologic complications of AIDS, with or without a history of drug or alcohol use. Recent advances in the development of the SIV model system highlight the power of animal model systems for study of the mechanisms underlying the pathology associated with lentiviral infection in the nervous system. These models will be key for developing therapeutic approaches for the treatment of patients suffering from NeuroAIDS and for understanding the basic biology of infection with HIV/AIDS. -Mechanism of Support. This funding opportunity will use the NIH Research Project (R21) award mechanism, and runs in parallel with a FOA of identical scientific scope, PAS-08-178, that encourages applications under the NIH Research Project Grant (R01) award mechanism. For research projects with limited scope to develop animal or ex vivo models, applicants may submit their application in response to the NIH Small Research Grant Program (R03): http://grants.nih.gov/grants/guide/pa-files/PA-06-180.html

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