Novel Tools for Investigating Brain-derived GPCRs in Mental Health Research (STTR [R41/R42])

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This funding opportunity announcement (FOA) solicits Small Business Technology Transfer (STTR) grant applications from small business concerns (SBCs) that propose to develop technologies and approaches (i.e., novel ways to use new or existing technologies) that will enable researchers to study the structure and/or function of brain localized G-protein coupled receptor proteins (GPCRs) and/or potentially identify novel selective and specific agonists/antagonists to these receptor subtypes, with a focus on mental health function or dysfunction. Technologies and approaches aimed at known receptor subtypes or orphan receptors would be of potential interest to NIMH. -Budgets up to $250,000 total costs per year and time periods up to 2 years for Phase I may be requested. Budgets up to $450,000 total costs per year and up to 3 years may be requested for Phase II. -No funds have been specifically set aside for this program; the number of awards and the amount of funds provided for awards have not been predetermined. -This FOA will utilize the STTR (R41/R42) grant mechanisms for Phase I, Phase II, and Fast-Track applications and runs in parallel with a FOA of identical scientific scope, PA-06-375 that solicits applications under the Small Business Innovation Research (SBIR) (R43/R44) grant mechanisms. -Eligible organizations: Only United States SBCs are eligible to submit STTR applications. A SBC is one that, on the date of award for both Phase I and Phase II funding agreements, meets ALL of the criteria as described in Section III. -Eligible individuals: Any individual with the skills, knowledge, and resources necessary to carry out the proposed research is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support. On an STTR application, the Project Director/Principal Investigator (PD/PI) may be employed with the SBC or the participating non-profit research institution as long as he/she has a formal appointment with or commitment to the applicant SBC, which is characterized by an official relationship between the small business concern and that individual. -Applicant SBCs may submit more than one application, provided each application is scientifically distinct.

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