Obstetric Pharmacology Research Units (U10)

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Purpose. The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) invites applications to participate in the Obstetric Pharmacology Research Units (OPRU) Network to serve as a resource for performance of pharmacologic studies of drug disposition and effect during normal and abnormal pregnancies. Within the Network, the OPRUs will: (1) conduct multi-site cooperative clinical studies of therapeutic modalities used during pregnancy; (2) conduct studies of fetal, placental and maternal pharmacology; (3) conduct studies on the effect of pregnancy on drug metabolizing enzymes, transporters and effectors, including interactions with pharmacogenetics/pharmacogenomics; (4) facilitate the collection and utilization of clinical materials for basic research studies; and (5) perform studies of placental metabolism and transfer of drugs; (6) enhance the exchange of information between basic scientists and obstetricians and among various specialists involved in treating pregnant women; (7) promote collaborations in interdisciplinary translational research. The Network will also serve as a resource for the training of health professionals, including pre- and post-doctoral fellows and PharmDs, in obstetric pharmacology, pharmacogenomics and clinical trials in pregnant women.

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