Oncology Models Forum (U24)

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The purpose of this Funding Opportunity Announcement (FOA) is to invite Cooperative Agreement (U24) applications that propose to establish and maintain an "Oncology Models Forum". Despite the growing adoption of pre-clinical mouse and human-in-mouse models for translational cancer research, NCI-supported investigators have no comprehensive resource for information to guide generating, validating, and credentialing new models, informing their practical uses, advancing modeling technologies, or providing catalogs of available models resources, programs, and services. The Forum to be supported under this FOA will be expected to fill this gap. The Forum focus is anticipated to be on effective, reliable use of mice, mouse models, and human-in-mouse models in translational cancer research, and other mouse modeling needs that the scientific community identifies. To address these goals, the Forum will be based on an online infrastructure using an existing platform, NCIP Hub. This platform can support, for example, real-time collaborations using shared mouse model and human molecular and genomic datasets and appropriate tools for cross-species analyses, and radiology image files and pathology whole slide images and software for image analysis and annotation, as well as developing and deploying educational materials and videos. The NCI will assist the Forum awardees to leverage and enhance the community-building, research collaboration, and education capabilities of NCIP Hub.

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