Pharmacogenomics Knowledge Base, PharmGKB (R24)

archived

Purpose. The purpose of this funding opportunity issued by NIGMS is to enable new and renewal applications to compete for the Pharmacogenetics and Pharmacogenomics Knowledge Base, PharmGKB (www.pharmgkb.org), which will be renamed the Pharmacogenomics Knowledge Base. PharmGKB is being developed to serve the needs of the entire research community in pharmacogenomics. Optimally, the knowledge base PharmGKB will present complete, comprehensive, and current knowledge in pharmacogenomics, backed by the critical datasets (which may be archived elsewhere) and the most compelling literature. There are informatics challenges to managing and integrating large and disparate sets of information, and a compelling resource should be easily used and extremely valuable to stakeholders trying to advance the field of pharmacogenomics and its implementation. The ultimate goal of pharmacogenomics is to guide appropriate therapeutic choices, and PharmGKB should support and extend modern research approaches to achieve this goal. Previously, PharmGKB was a component of the Pharmacogenetics Research Network; now the network is the subject of another funding opportunity announcement (Pharmacogenomics Research Network, RFA-GM-10-001, http://grants.nih.gov/grants/guide/rfa-files/RFA-GM-10-001.html). PharmGKB is being renewed separately as a R24 in order to enable the knowledge base to be developed to clearly serve the needs of the entire research community in pharmacogenomics.

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