Pharmacogenomics Research Network (U01/U19)

archived

Purpose. The purpose of this funding opportunity announcement issued by NIGMS, NHLBI, NCI, NIDA, NIMH, and NICHD is to allow new and renewal applications for research groups to compete to become part of the Pharmacogenomics Research Network (PGRN), and to create network resources that serve the entire PGRN. The PGRN is a consortium of interdisciplinary groups with a core mission to conduct research into understanding the genetic basis of variable drug responses, both therapeutic and adverse. The scientific objectives of the research network include definition of the pressing problems for safe and effective use of medications, establishment of truly cross-disciplinary research groups, application of the most appropriate genetic and genomic methods to important sample collections, discovery and replication studies that identify variation in critical genes and biological pathways, elucidation of the functional consequences of genetic variation for the drugs being studied, and understanding the clinical implications of genotyping to predict drug responses

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