Physiology and physiopathology of the fluids, tissues, pressure interactions in the human central nervous system

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Main objective : The main objective of the INTRAMES project is to improve in the short-term the care of patients struck down by cerebral hydro-dynamical disorders, by jointly developing a new diagnosis and investigation tool for these disorders. The second objective lies in the global understanding of cerebral hydrodynamics. To reach this goal, INTRAMES plans to build the first multicompartmental (CSF, blood, brain) phantom to study in-vitro, during an infusion test, the interactions between CSF (cerebrospinal fluid) flow and ICP (intracranial pressure) starting from a shared methodological approach. Main actions : - Setting up in Cambridge of the MRI flow acquisition and analysis methods previously developed in Amiens. - Development of a software combining CSF and blood flow measurements resulting from MRI acquisition and direct measurements of intracranial pressure. - Design of the phantom - Study of the relationships between biological fluids, tissues and pressure via the phantom. - Utilization of the phantom within the framework of an infusion test simulation - Study of the impact of endoscopic ventriculocisternostomy on cerebral hydrodynamics with the participation of the neurosurgery department of Amiens - Exploitation and improvement of the numerical model (Cambridge) of CSF circulation using MRI measurements data (Amiens)

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