Plasticity and Mechanisms of Cognitive Remediation in Older Adults (R01)

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This funding opportunity announcement (FOA) solicits R01 grant applications from applicant organizations that propose to develop and implement interventions to remediate age-related cognitive decline. A crucial feature of these applications will be the embedding of the testing of the proposed intervention into a measurement framework that will: 1) help elucidate its mechanism of action; 2) identify specific individuals who are more likely or less likely to benefit from the intervention, and 3) examine whether adaptive plastic changes have occurred in the structure or function of the CNS as a result of the intervention, and whether these neural changes help explain the pattern of improvement seen in cognitive functioning. Although projects may include an observational component, the interventions developed should be tested in a randomized clinical trial (RCT).

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