Population-based Research Optimizing Screening through Personalized Regimens (PROSPR) (U54)

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Purpose. This Funding Opportunity Announcement (FOA) is part of a new program on population-based research to optimize screening through personalized regimens (PROSPR). PROSPRs overall purpose is to promote coordinated, multidisciplinary research to evaluate and improve the cancer screening process (recruitment, screening, diagnosis, referral for treatment). Specifically, this FOA is designed to promote coordinated, multidisciplinary research regarding the screening processes for breast, colon or cervical cancer by supporting PROSPR Research Centers. Each center proposed in response to this FOA must have a research program that includes a plan to collect data on individual patients during their usual course of care through the screening process. The data must be relevant to documenting and evaluating the entire screening process for one of these three cancer types. The program must also include 3 interrelated research projects pertinent to understanding factors influencing the screening process, such as communication about screening; patient risk factors; screening test characteristics; the diagnostic process; behavior of patients and health services providers; economics of screening; and/or factors in the health care organization and delivery environment. Research Center applicants are expected to build a thematically driven multidisciplinary research team with relevant expertise. The team must have appropriate collaborations with a network of screening and diagnostic services providers to serve as the source of data and clinical insight. Investigators at the PROSPR Research Centers will be expected to collaborate with each other, the NCI and the single Statistical Coordination Center.

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