Prescription Drug Misuse (R03)

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-Purpose. The National Institute on Drug Abuse and the National Institute of Mental Health invites research applications to reduce prescription drug misuse while supporting the appropriate medical use of therapeutic agents that carry an abuse liability. A range of research is being solicited to combat prescription drug misusefrom epidemiologic research specifying the extent and nature of the problem (including physical and mental health and social consequences) as it relates to each specific drug and identifying determinants and trajectories of use. Basic science applications to determine mechanisms of action at the cellular level and possible mechanisms or medications to block or lessen the abuse potential are encouraged, as are health services applications with the goal of discovering effective clinical practices that identify those at risk and designing and disseminating prevention and treatment interventions.  -The R03 grant mechanism supports different types of projects including pilot and feasibility studies; secondary analysis of existing data; small, self-contained research projects; development of research methodology; and development of new research technology. The R03 is intended to support small research projects that can be carried out in a short period of time with limited resources. -Mechanism of Support. This FOA will utilize the NIH Small Research Grant (R03) award mechanism and runs in parallel with an FOA of identical scientific scope, PA-08-127, that encourages applications under the R01mechanism and PA-08-128 that encourages applications under the R21 mechanism. -Funds Available and Anticipated Number of Awards. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received.

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