Program Development and Research to Establish and Evaluate Innovative and Emerging Best Practices in Clinical and Community Services through the Presidents Emergency Plan for AIDS Relief (PEPFAR): Amendment 2

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The PEPFAR Stewardship and Oversight ACT of 2013 calls for the integration of timely and relevant operational research for the purposes of improving program quality and efficiency, ascertaining cost effectiveness, assessing population-based impact, and optimizing delivery of services. The 2015 strategy paper PEPFAR 3.0: Controlling the Epidemic: Delivering on the Promise of an AIDS-free Generation calls for a focus on strategic, scientifically sound investments to rapidly scale-up and maximize impact of core HIV prevention, treatment and care interventions.In order to meet these high level programmatic goals, evaluation and research activities that establish and strengthen innovative, emerging best practices in clinical and community HIV/AIDS and TB prevention, care, and treatment service programs are needed. Findings provided by evaluation and research activities will help establish the metrics and benchmarks for defining and measuring success. Evaluation and research activities, including formative assessments, economic evaluations, program process, outcome, and impact evaluations, implementation science, and research activities, will ultimately lead to improvements in program quality and efficiency, cost effectiveness, population-based impact, and service delivery optimization. As such, the U.S. Government (USG) recognizes and supports this funding announcement to support public and nonprofit private institutions and agencies with host-country investigators in PEPFAR-supported countries for the conduct of program development and research activities with the objective of the rapid dissemination of conclusions and concrete impact on programming.This FOA directly supports evaluation and research activities to develop an evidence base that supports the global implementation of clinical and community HIV/AIDS and TB prevention, care, and treatment services. Effective projects are those that expand the evidence base that informs national priorities and implementation plans and results in replicable models and defines strategies for priority interventions.

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