Research Grants Using the Resources from the Osteoarthritis Initiative (OAI)(R21)

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This Funding Opportunity Announcement (FOA) encourages applications focused on the use the Osteoarthritis Initiative (OAI) database, clinical data and images. This FOA seeks to expand the use of these resources by investigators in the broader research community. Examples of possible topics are: identification and validation of risk factors for knee and hip OA, including both modifiable and non-modifiable risk factors; utilization of biospecimens in conjunction with research efforts to determine biochemical markers of early and/or progressive disease; analyses of existing OAI data to assess the effectiveness of biobehavioral, pharmacological, and other interventions that subjects use in response to OA pain; determination of predictive role of MRI changes for subsequent radiographic and clinical outcome changes related to development of knee OA; development of novel and efficient tools for analysis of MR images and x rays that can be applied to large numbers of images with high degrees of reproducibility for diagnosis and monitoring of OA-related changes; and research focused on the trajectory of disease including effects on other joint structures such as muscles, ligaments, and bone, with regard to points where interventions could be made, especially for subsets, to reduce OA severity. The publication of this FOA to the research community indicates to investigators and peer reviewers the importance that the NIAMS and other partners have placed on the use of the OAI resources.

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