Research on Malignancies in the Context of HIV/AIDS (R01)

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-Purpose. The purpose of this funding opportunity announcement (FOA) is to advance our understanding of the risks, development, progression, diagnosis, and treatment of malignancies observed in individuals with an underlying Human Immunodeficiency (HIV) infection or Acquired Immune Deficiency Syndrome (AIDS). Through this FOA, the NCI and NIDCR seek to encourage research in areas such as the study of the etiologic factors, cofactors, pathogenesis, and consequences of HIV-associated malignancies in [the members of] diverse populations. Research on non-AIDS defining malignancies in the context of HIV infection is also encouraged. The incidence of non-AIDS-defining malignancies (e.g., anal, skin, and lung cancers as well as Hodgkin s disease) appear to be increasing in the era of Highly Active Antiretroviral Treatment (HAART). This FOA extends to research efforts that will (i) provide information on the clinical outcomes of such cancers in the HIV-infected population and (ii) identify specific contributions resulting from HIV infection for the development and pathogenesis of these cancers. Ultimately, such efforts could inform screening approaches and therapies targeted to the HIV-infected population.

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