Revolutionary Genome Sequencing Technologies The $1000 Genome (R01)

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Purpose. The National Human Genome Research Institute (NHGRI) solicits R01 grant applications to develop novel technologies that will enable extremely low-cost, high quality DNA sequencing. The goal of this initiative is to reduce the cost of sequencing a mammalian-sized genome to approximately $1000. Applicants may propose to develop full-scale sequencing systems or to investigate challenges underlying key system components. Exploration of methods other than those currently being pursued as potential $1,000 genome technologies are encouraged. High-risk/high-payoff applications are appropriate to achieve the goals of this FOA by approximately 2014. Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism and runs in parallel with FOAs of identical scientific scope, RFA-HG-10-013 and RFA-HG-10-014, that encourage applications under the R21 and R43/R44 mechanisms, respectively. Funds Available and Anticipated Number of Awards. Contingent upon the availability of funds and the receipt of a sufficient number of meritorious applications, the NHGRI may make 2-7 awards and may award $5 million total costs in each of FY2011, FY 2012, and FY 2013 in response to this FOA.

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