Revolutionary Genome Sequencing Technologies The $1000 Genome (R01)

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Purpose. The National Human Genome Research Institute (NHGRI) solicits R01 grant applications to develop novel technologies that will enable extremely low-cost, high quality DNA sequencing. The goal of this initiative is to reduce the cost of sequencing a mammalian-sized genome to approximately $1000. Applicants may propose to develop full-scale sequencing systems or to investigate challenges underlying key system components. Exploration of methods other than those currently being pursued as potential $1,000 genome technologies are encouraged. High-risk/high-payoff proposals are appropriate to achieve the goals of this FOA by approximately 2014. Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) grant mechanism and runs in parallel with FOAs of identical scientific scope, RFA-HG-09-012 and RFA-HG-09-013 that solicit applications under the R21 and R43/R44 mechanisms. Funds Available and Anticipated Number of Awards. Contingent upon the availability of funds and the receipt of a sufficient number of meritorious applications, the NHGRI may make 2-7 awards and may award $5 million total costs in FY2010 and again in FY2011 in response to this FOA.

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