Revolutionary Genome Sequencing Technologies The $1000 Genome (R21)

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Purpose. The National Human Genome Research Institute (NHGRI) solicits R21 grant applications to develop novel technologies that will enable extremely low-cost, high quality DNA sequencing. The goal of this initiative is to reduce the cost of sequencing a mammalian-sized genome to approximately $1000. Applicants may propose to develop full-scale sequencing systems or to investigate challenges underlying key system components. Exploration of methods other than those currently being pursued as potential $1,000 genome technologies are encouraged. High-risk/high-payoff proposals are appropriate to achieve the goals of this FOA by approximately 2014. Mechanism of Support. This FOA will utilize the NIH Exploratory/Developmental Research (R21) grant mechanism and runs in parallel with FOAs of identical scientific scope, RFA-HG-09-011 and RFA-HG-09-013 that solicit applications under the R01 and R43/R44 mechanisms. Funds Available and Anticipated Number of Awards. Contingent upon the availability of funds and the receipt of a sufficient number of meritorious applications, the NHGRI may make 2-7 awards and may award $2 million total costs in FY2010 and again in FY2011 in response to this FOA.

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