Revolutionary Genome Sequencing Technologies The $1000 Genome (SBIR [R43/R44])

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Purpose. This Funding Opportunity Announcement (FOA) solicits Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that propose to develop novel technologies that will enable extremely low-cost, high quality DNA sequencing. The goal of this initiative is to reduce the cost of sequencing a mammalian-sized genome to approximately $1000. Applicants may propose to develop full-scale sequencing systems or to investigate challenges underlying key system components. Exploration of methods other than those currently being pursued as potential $1,000 genome technologies are particularly encouraged. High-risk/high-payoff proposals are appropriate to achieve the goals of this FOA by approximately 2014. Mechanism of Support. This FOA will utilize the SBIR (R43/R44) grant mechanisms for Phase I, Phase II, and Fast-Track applications and runs in parallel with a FOA of identical scientific scope, RFA-HG-09-011 and RFA-HG-09-012 that solicit applications under the R01 and R21 mechanisms. Funds Available and Anticipated Number of Awards. The estimated amount of funds available for support of 2-5 projects awarded as a result of this announcement is $2.5 million for fiscal year 2010. Future year amounts will depend on annual appropriations.

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